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Yayın Erişkin dikkat eksikliği hiperaktivite bozukluğunda tepki ketleme ve enterferans kontrolü(Türk Nöropsikiyatri Derneği, 2023) Arat Çelik, Hidayet Ece; Küçükgöncü, Suat; Erdoğan, Ayşe; Özerdem, Ayşegülİnhibitör kontrol, dikkat eksikliği hiperaktivite bozukluğunda (DEHB) yürütücü işlevlerde bozulmanın görüldüğü temel alanlardan biridir. İnhibitör kontrol tepki ketleme ve enterferans kontrolü gibi bileşenlerden oluşmaktadır. Dikkat eksikliği hiperaktivite bozukluğunda inhibitör kontrolün hangi bileşenlerinde bozulma olduğunun saptanması, ayırıcı tanı ve tedavi açısından faydalı olacaktır. Bu çalışmada erişkin DEHB’de tepki ketleme ve enterferans kontrolünün ne şekilde etkilendiğinin araştırılması amaçlanmıştır. Yöntem: Çalışmaya 42 erişkin DEHB tanılı birey ve 43 sağlıklı kontrol (SK) dâhil edilmiştir. Tepki ketleme ve enterferans kontrolünün değerlendirilmesi amacıyla Dur İşareti Testi (DİT) ve Stroop Test kullanılmıştır. Hasta ve SK grupların DİT ve Stroop test açısından karşılaştırılmasında, yaş ve eğitim düzeyi eş değişken olarak alınarak, MANCOVA kullanılmıştır. Dur İşareti Testi ve Stroop Test ile Barrat Dürtüsellik Ölçeği-11 (BDÖ-11) arasındaki ilişkiye Pearson korelasyon analizi ile bakılmıştır. Erişkin DEHB tanılı bireylerde psikostimülan kullanan ve kullanmayan bireyler arasında testlerin karşılaştırılması Mann Whitney-U testi ile yapılmıştır. Bulgular: Çalışmamızda DEHB tanılı bireylerde tepki ketlemenin SK’lere göre bozulduğu, enterferans kontrolünün ise SK’lerden farklılık göstermediği saptanmıştır. Dur işareti gecikmesi (DİG) ile BDÖ-11 dikkat, motor, plansızlık ve toplam puanları arasında zayıf ve orta düzeyde negatif yönde, dur işareti tepki süresi (DİTS) ile BDÖ-11 dikkat, motor, plansızlık ve toplam puanları arasında zayıf düzeyde pozitif yönde ilişki bulunmuştur. Metilfenidat tedavisi alan DEHB tanılı bireylerde, almayanlara göre tepki ketleme becerilerinde anlamlı düzelme olduğu, BDÖ-11 ile ölçülen dürtüsellik düzeylerinin de gerilediği saptanmıştır. Sonuç: İnhibitör kontrol çatısı altında ele alınan tepki ketleme ve enterferans kontrolünün erişkin DEHB tanılı bireylerde farklı özellikler gösterebileceği ve bunun ayırıcı tanı açısından önemli olduğu unutulmamalıdır. Psikostimülan tedaviyle tepki ketleme becerisinde düzelme olduğu, bu durumun hastanın da fark edeceği şekilde olumlu olarak hissedildiği söylenebilir. Hastalığın nörofizyopatolojik mekanizmalarını anlamak, buna uygun tedaviler geliştirmek açısından faydalı olacaktır.Yayın Oxidative DNA base damage and base excision repair abnormalities in siblings of individuals with bipolar disorder(Research Square, 2023) Çelik, Hidayet Ece; Yılmaz, Seda; Kendirlioğlu, Burcu Kök; Çörekli, Esma; Bekar, Nazlı Dal; Çelik, Ömer; Yorguner, Neşe; Öztürk, Bilge Targıtay; İşlekel, Hüray; Özerdem, Ayşegül; Akan, Pınar; Ceylan, Deniz; Tuna, GamzePrevious evidence suggests elevated levels of oxidative DNA damage, particularly 8-hydroxy-2'- deoxyguanosine (8-OH-dG), and abnormalities in the repair of 8-OH-dG by the base excision repair (BER) in BD. However, the genetic disposition of these abnormalities remains unknown. In this study, we aimed to investigate the levels of oxidative DNA damage and BER mechanisms in individuals with BD and their siblings, as compared to healthy controls (HCs). 46 individuals with BD, 41 siblings of individuals with BD, and 51 HCs were included in the study. Liquid chromatography-tandem mass spectrometry was employed to evaluate the levels of 8-OH-dG in urine, which were then normalized based on urine creatinine levels. The real-time-polymerase chain reaction was used to measure the expression levels of 8-oxoguanine DNA glycosylase 1 (OGG1), apurinic/apyrimidinic endonuclease 1 (APE1), poly ADP-ribose polymerase 1 (PARP1), and DNA polymerase beta (POL?). The levels of 8-OH-dG were found to be elevated in both individuals with BD and their siblings when compared to the HCs. The OGG1 and APE1 expressions were downregulated, while POL? expressions were upregulated in both the patient and sibling groups compared to the HCs. Age, smoking status, and the number of depressive episodes had an impact on APE1 expression levels in the patient group while body mass index, smoking status, and past psychiatric history had an impact on 8-OH-dG levels in siblings. Both individuals with BD and unaffected siblings presented similar abnormalities regarding oxidative DNA damage and BER, suggesting a link between abnormalities in DNA damage / BER mechanisms and familial susceptibility to BD. Our findings suggest that targeting the oxidative DNA damage and BER pathway could offer promising therapeutic strategies for reducing the risk of age-related diseases and comorbidities in individuals with a genetic predisposition to BD.Yayın Quality of Life of Individuals with Bipolar Disorder and Schizophrenia(Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi, 2022) Çelik, Hidayet Ece Arat; Ceylan, Deniz; Bagci, Basak; Akdede, Berna Binnur; Alptekin, Koksal; Özerdem, AyşegülIntroduction: Quality of life (QoL) is a concept defined as a subjective perception of one's position in life and is negatively affected in many psychiatric illnesses such as bipolar disorder (BD) and schizophrenia (SCZ). It is hypothesized that therapeutic approaches based on QoL can increase the patient's adherence to treatment and contribute to a satisfactory life. This study aimed to compare the QoL of individuals having BD and schizophrenia with that of healthy controls (HCs) and to investigate the impact of the state of remission on QoL.Method: The World Health Organization QoL Scale-Short Form (WHOQOL-Bref) was administered to individuals with BD (n=124) and SCZ (n=74) and to HCs (n=81) to evaluate QoL. The WHOQOL-Bref subscale and total scores were compared between the groups using multifactor analysis of covariance (MANCOVA) by considering age and education level as the covariates. Then, the patient groups were compared using MANCOVA based on the state of remission by taking age, level of education, and Global Assessment of Functioning scores as the covariates. The relationship between clinical features and QoL scores was evaluated using correlation analysis, and linear regression analysis was applied for the variables that were found to be significant.Results: It was found that individuals with SCZ or BD had lower WHOQOL-Bref psychological, social, and total scores than HCs. Those with SCZ additionally had lower physical and environmental subscale scores than HCs. Furthermore, those with SCZ had lower WHOQOL-Bref physical, psychological, social, and total scores than individuals with BD. There was no significant difference in WHOQOL-Bref scores between individuals with BD and SCZ in the remission period. WHOQOL-Bref physical, psychological, and total scores were found to be significantly lower in unremitted BD patients when compared with remitted BD patients. Unremitted BD patients were found to have significantly lower WHOQOL-Bref psychological, environmental, and total scale scores than unremitted SCZ patients. Conclusion: It can be concluded that the QoL of individuals with BD is between that of healthy individuals and those with SCZ. However, unremitted BD patients have lower QoL than unremitted SCZ patients. Both patient groups display similar features during remission. Identifying the similarities and differences in terms of QoL in both patient groups is of great importance to develop the best type of treatment for the patients.Yayın What does the broken brain say to the neuroscientist? Oscillations and connectivity in schizophrenia, Alzheimer's disease, and bipolar disorder(Elsevier Science BV, 2016) Basar, Erol; Schmiedt-Fehr, Christina; Mathes, Birgit; Femir, Banu; Emek-Savas, Derya Durusu; Tülay, Elif; Tan, Devran; Düzgün, Aysel; Güntekin, Bahar; Özerdem, Ayşegül; Yener, Görsev; Başar-Eroğlu, CananThe application of the concept and methods of brain oscillations has been an important research area in neurosciences. In the last decades, besides the application in cognitive processes, the study of changes in brain oscillations in diseases has also become an important focal point of research. In the present paper, some remarkable examples in three different diseases are taken into consideration: 1) schizophrenia (SZ), 2) Alzheimer's disease (AD), 3) bipolar disorders (BD). In the current literature, decreased oscillations in cortical recordings are observed in most of the pathologies. For example, decrease of gamma activity in SZ, decrease of delta activity in almost all diseases, as well as frequency shifts in alpha and the lower frequencies were recorded. However, there are also paradoxical cases in which an increase of oscillatory activities is observed. In BD, whereas alpha activity is greatly decreased, a huge increase of beta activity is observed. Or, in SZ, a paradoxical increase of gamma activity can be observed during cognitive loading. We also observed paradoxical changes in the analysis of connectivity. In AD, we find that alpha, delta, and theta coherences between distant parts of the cortex are greatly decreased, whereas in the gamma band, event-related coherences attain very high values. The comparison of the results and paradoxical changes in diseases may lead to important conclusions related to the web of oscillations and neurotransmitters. In turn, we could gain new insights to approach "brain function", in general. (C) 2016 The Authors. Published by Elsevier B.V.
