Protective Effect of Zinc Aspartate on Long-Term Ischemia-Reperfusion Injury in Rat Skeletal Muscle

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dc.contributor.authorAtahan, Erhan
dc.contributor.authorErgun, Yusuf
dc.contributor.authorKurutas, Ergul Belge
dc.contributor.authorAlici, Tugrul
dc.date.accessioned2024-07-12T21:45:13Z
dc.date.available2024-07-12T21:45:13Z
dc.date.issued2010en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractThe present study investigated the protective effect of zinc aspartate, in connection with reactive oxygen species and nitric oxide, on long-term ischemia-reperfusion injury (IRI) in rat skeletal muscle. Following ketamine anesthesia, 24 rats were randomly assigned to four groups: groups 1 and 2, each without tourniquet application, received no drug and zinc, respectively; groups 3 and 4, each subjected to tourniquet-induced IRI (3 + 24 h), received no drug and zinc, respectively. IRI was achieved by the application of an elastic rubber band in the left hind limb of the anesthetized rats. Gastrocnemius muscle samples were obtained for biochemical measurements. Malondialdehyde levels were lower in group 2 and higher in group 3 than those seen in group 1. However, zinc aspartate (group 4) totally reversed malondialdehyde levels to control levels. Superoxide dismutase activity was increased in group 2 compared with group 1; however, there was no difference between groups 1 and 3, and Zn injection (group 4) increased superoxide dismutase activity. While catalase values were similar in groups 1 and 2, significant increments were observed in 3 and 4. A similar enhancement in glutathione levels were observed in groups 2 and 4 compared with group 1. Nitric oxide levels were lower in group 2 than 1, and no difference between groups 1 and 3 was demonstrated. In conclusion, zinc seems to be an effective treatment option against IRI.en_US
dc.identifier.doi10.1007/s12011-009-8568-6
dc.identifier.endpage215en_US
dc.identifier.issn0163-4984
dc.identifier.issue2en_US
dc.identifier.pmid19937281en_US
dc.identifier.scopus2-s2.0-79952110118en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage206en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s12011-009-8568-6
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7811
dc.identifier.volume137en_US
dc.identifier.wosWOS:000281667800008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherHUMANA PRESS INCen_US
dc.relation.ispartofBIOLOGICAL TRACE ELEMENT RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00414
dc.subjectZincen_US
dc.subjectIschemia-reperfusion injuryen_US
dc.subjectAntioxidantsen_US
dc.subjectSkeletal muscleen_US
dc.subjectNitric oxideen_US
dc.titleProtective Effect of Zinc Aspartate on Long-Term Ischemia-Reperfusion Injury in Rat Skeletal Muscleen_US
dc.typeArticle
dspace.entity.typePublication

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