Increased asymmetric dimethylarginine levels in young men with familial Mediterranean fever (FMF): is it early evidence of interaction between inflammation and endothelial dysfunction in FMF?

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dc.authorid0000-0003-2045-1709en_US
dc.authorid0000-0003-1110-6671en_US
dc.authorid0000-0003-4170-7865en_US
dc.contributor.authorTerekeci, Murat Hakan
dc.contributor.authorÖktenli, Çağatay
dc.contributor.authorÖzgürtaş, Taner
dc.contributor.authorNalbant, Selim
dc.contributor.authorTop, Cihan
dc.contributor.authorÇelik, Serkan
dc.contributor.authorTapan, Serkan
dc.contributor.authorKüçükardalı, Yaşar
dc.contributor.authorSanisoğlu, Yavuz S.
dc.contributor.authorSolmazgül, Emrullah
dc.contributor.authorŞahan, Burak
dc.contributor.authorSayan, Özkan
dc.date.accessioned2024-07-12T21:11:39Z
dc.date.available2024-07-12T21:11:39Z
dc.date.issued2008en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractObjective: Unlike in many other chronic inflammatory rheumatic diseases, studies investigating endothelial dysfunction and atherosclerosis in familial Mediterranean fever (FMF) are limited, and the results are controversial. Asymmetric dimethylarginine (ADMA) is considered an indicator for endothelial dysfunction and a sensitive marker for cardiovascular risk. There have been no reports on serum ADMA levels in patients with FMF. Methods: We aimed (1) to determine serum ADMA concentrations in 38 young male patients with FMF and 23 age- and body mass index-matched healthy volunteers; (2) to evaluate its correlations with MEFV mutations, C-reactive protein (CRP) levels, and lipid profile; and (3) to compare effects of colchicine on circulating ADMA concentrations. Results: In patients with FMF, ADMA and CRP levels were higher than in healthy controls. The mean levels of ADMA and CRP were higher during acute attacks than in attack-free periods. Patients taking colchicine had lower serum ADMA levels than non-colchicine users. There was a positive strong correlation between ADMA and CRP in patients with FMF. Stepwise linear regression analysis in patients with FMF revealed that age and CRP levels were independently associated with serum ADMA levels. Conclusion: Our data imply that higher serum ADMA levels in FMF may indicate inflammation-related "endothelial dysfunction." It seems likely that regular use of colchicine is effective in preventing the development of and reversing not only amyloidosis but also endothelial dysfunction in patients with FMF.en_US
dc.identifier.citationTerekeci H.M., Öktenli C., Özgürtaş T., Nalbant S., Top C., Çelik S., Tapan S., Küçükardalı Y., Sanisoğlu Y.S., Solmazgül E., Şahan B. ve Sayan O. (2008). Increased asymmetric dimethylarginine levels in young men with familial Mediterranean fever (FMF): is it early evidence of interaction between inflammation and endothelial dysfunction in FMF?. The Journal of Rheumatology, The Journal of Rheumatology Publishing Co. Ltd. 35(10), s. 2024-2029.en_US
dc.identifier.endpage2029en_US
dc.identifier.issn0315-162X
dc.identifier.issn1499-2752
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2024en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/18785307/
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4389
dc.identifier.volume35en_US
dc.language.isoenen_US
dc.publisherThe Journal of Rheumatology Publishing Co. Ltd.en_US
dc.relation.ispartofThe Journal of Rheumatologyen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY03558
dc.titleIncreased asymmetric dimethylarginine levels in young men with familial Mediterranean fever (FMF): is it early evidence of interaction between inflammation and endothelial dysfunction in FMF?en_US
dc.typeArticle
dspace.entity.typePublication

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